The role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia.

To explore the clinical application value of chest CT quantitative pulmonary inflammation index (PII) in the evaluation of the course and treatment outcome of COVID-19 pneumonia. One hundred and eighteen patients with COVID-19 pneumonia diagnosed by RT-PCR were analyzed retrospectively. The correlation between chest CT PII, clinical symptoms and laboratory examinations during the entire hospitalization period was compared. The average age of the patients was 46.0 ± 15 (range: 1-74) years. Of the 118 patients, 62 are male (52.5%) and 56 are female (47.5%). Among them, 116 patients recovered and were discharged, 2 patients died, and the median length of hospital stay was 22 (range: 9-41) days. On admission, 76.3% of the patients presented with fever, and the laboratory studies showed a decrease in lymphocyte (LYM) count and an increase in lactate dehydrogenase (LDH) levels, C-reactive protein (CRP) levels, and erythrocyte sedimentation rate (ESR). Within the studies' chest CTs, the median number of involved lung lobes was 4 (range: 0-5) and the median number of involved lung segments was 9 (range 0-20). The left lower lobe and the right lower lobe were the most likely areas to be involved (89.0% and 83.9%), and 84.7% of the patients had inflammatory changes in both lungs. The main manifestations on chest CT were ground glass opacities (31.4%), ground glass opacities and consolidation (20.3%), ground glass opacities and reticular patterns (32.2%), mixed type (13.6%), and white lungs (1.7%); common accompanying signs included linear opacities (55.9%), air bronchograms (46.6%), thick small vessel shadows (36.4%), and pleural hypertrophy (13.6%). The chest CT at discharge showed complete absorption of lesions in 19 cases (16.1%), but not in the remaining 99 cases. Lesions remained in a median of 3 lung lobes (range: 0-5). Residual lesions remained in a median of 5 lung segments (range: 0-20). The residual lesions mainly presented as ground glass opacities (61.0%), and the main accompanying sign was linear opacities (59.3%). Based on chest CT, the median maximum PII of lungs was 30.0% (range: 0-97.5%), and the median PII after discharge in the patients excluding the two deaths was 12.5% (range: 0-53.0%). PII was significantly negatively correlated with the LYM count and significantly positively correlated with body temperature, LDH, CRP, and ESR. There was no significant correlation between the PII and the white blood cell count, but the grade of PII correlated well with the clinical classification. PII can be used to monitor the severity and the treatment outcome of COVID-19 pneumonia, provide help for clinical classification, assist in treatment plan adjustments and aid assessments for discharge.

Thoughts on innovation and entrepreneurship mode reform of college students in the context of COVID-19

The employment difficulty of modern college students has become one of the common problems in the society, and the diversified employment model of entrepreneurship as employment pull has become an effective way to enhance the employment rate and boost the social and economic development. The innovative and venture education into the whole procedure of talent training has become a new education concept and reached a consensus. However, this mode of education is not immutable. Under the background of major social events and emergent social problems, creation and entrepreneurship education is faced with the challenge of mechanism and way. The research perspective of this paper is based on the multiple psychological and operational crises brought to entrepreneurs and entrepreneurs by industrial structure contradictions and marketing mode changes in the social environment of COVID-19 public events. How to turn the crisis into a business opportunity through flexible and diversified innovation education and entrepreneurship support, and better accomplish the task of creation and entrepreneurship by changing creation and entrepreneurship education and practice in various turbulent situations? Under the background of COVID-19 epidemic, this paper proposes solutions to problems existing in the practice of contemporary college students, and discusses new modes of creation and entrepreneurship for academy students.

Clinical effect of millimeter wave applied to acupoints on treatment of COVID-19

OBJECTIVE: To retrospectively observe the clinical effect of integrated Chinese and Western medicine combined with millimeter wave therapy on treatment of non-critical COVID-19 patients. METHODS: A total of 47 patients with COVID-19 who were treated in the People's Hospital of Hong'an County from Feb 2, 2020 to Feb 19, 2020 were enrolled in the study, the patients were given integrated Chinese and Western medicine therapies such as oxygen therapy, antiviral treatment, supportive treatment and Chinese patent medicine, and the millimeter wave therapy was applied to the acupoints twice a day. The respiratory function indexes such as oxygenation index and oxyhemoglobin saturation, chest CT, number of times of cough in a day and blood test indexes were collected after the millimeter wave treatment system was used for 1 day (T1), 3 days (T2), 10 days (T3) and 14 days (T4). RESULTS: The oxygenation index and blood oxygen saturation of the 47 patients were significantly higher at T2, T3 and T4 than at T1 after the integrated Chinese and Western medicine combined with millimeter wave therapy (P<0.05). There was significant difference in the percentage of the patients with grade 3 chest CT among all the time points except for T2 and T1 (P<0.05). There were significant differences in the number of times of cough and body temperature between the time points and T1 (P<0.05). The lactic dehydrogenase(LDH) level was slowly reduced, and there was significant difference between T4 and T1 (P<0.05). There were no significant differences in the white blood cell, lymphocyte, hemoglobin, potassium, sodium and chlorine at the admission. 4 patients were tested positive at T4, and the negative conversion ratio was 91.5%. CONCLUSION: The integrated Chinese and Western medicine combined with millimeter wave therapy can achieve remarkable effect on improvement of clinical symptoms of the COVID-19 patients such as oxygenation index and promote the nucleic acid to turn negative, and it has certain clinical application value.